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Microgram: fda-immunogenicity-risk

station__algovigilance__microgram-fda-immunogenicity-risk native (always callable) algovigilance pv-core Constructa Configa

FDA immunogenicity risk classification for therapeutic proteins: routes by product attributes and clinical impact per FDA Guidance 'Immunogenicity Assessment for Therapeutic Protein Products' (2014)

Taxonomy

Linnaean classification joined from the algovigilance taxonomy index via the parent config's rank.

Rank	Value
domain	`Substrata`
kingdom	`Constructa`
phylum	`Configa`
class	`station-config`
order	`algovigilance`
family	`mcp-tool-config`

Characteristics:

substrate: config
domain: pv
lifecycle: continuous
authority: read
compounding: producer
io: agent-request → tool-response

Input schema

product_origin stringrequired — Protein origin: human, humanized, chimeric, murine, novel
route_of_administration stringrequired — Route: iv, sc, im, intrathecal, topical
endogenous_counterpart boolean — Whether the protein has an endogenous counterpart (risk of cross-reactive antibodies)
clinical_consequence string — Consequence of immunogenicity: loss_of_efficacy, hypersensitivity, cross_neutralization, none

Example call

POST /api/mcp
Content-Type: application/json

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "station__algovigilance__microgram-fda-immunogenicity-risk",
    "arguments": {
      "product_origin": "",
      "route_of_administration": ""
    }
  }
}

How to invoke from a client

From any MCP-aware client, add https://algovigilance.com/api/mcp as an MCP server, then call this tool by name. From a raw HTTP client, send the JSON-RPC body above to /api/mcp.

Agent-friendly formats

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