# Microgram: fda-immunogenicity-risk

`station__algovigilance__microgram-fda-immunogenicity-risk` · native (always callable) · domain `algovigilance` · pv-relevance `pv-core`

FDA immunogenicity risk classification for therapeutic proteins: routes by product attributes and clinical impact per FDA Guidance 'Immunogenicity Assessment for Therapeutic Protein Products' (2014)

## Agent metadata

- `idempotent`: true
- `read_only`: true
- `expected_latency_ms`: unknown (not yet contract-tested)
- `cost_tokens_estimate`: unknown

## Input schema

- `product_origin` *string* (required) — Protein origin: human, humanized, chimeric, murine, novel
- `route_of_administration` *string* (required) — Route: iv, sc, im, intrathecal, topical
- `endogenous_counterpart` *boolean* — Whether the protein has an endogenous counterpart (risk of cross-reactive antibodies)
- `clinical_consequence` *string* — Consequence of immunogenicity: loss_of_efficacy, hypersensitivity, cross_neutralization, none

## Example call

```json
POST /api/mcp
Content-Type: application/json

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "station__algovigilance__microgram-fda-immunogenicity-risk",
    "arguments": {
      "product_origin": "",
      "route_of_administration": ""
    }
  }
}
```

## Related

- [/tools](/tools) — all 7718 tools
- [/tools/algovigilance__microgram-fda-immunogenicity-risk](/tools/algovigilance__microgram-fda-immunogenicity-risk) — HTML page
- [/tools/algovigilance__microgram-fda-immunogenicity-risk/json](/tools/algovigilance__microgram-fda-immunogenicity-risk/json) — JSON form (agent-friendly)
- [/api/mcp](/api/mcp) — endpoint
- [/AGENTS.md](/AGENTS.md) — agent guide