# assess-naranjo

`station__pv-engine__assess-naranjo` · external (needs EXECUTION_BACKEND_URL configured) · domain `pv-engine` · pv-relevance `pv-core`

Run the Naranjo Adverse Drug Reaction Probability Scale. Scores 10 questions about temporal relationship, dechallenge, rechallenge, alternative causes, dose-response, and objective evidence. Returns total score (range -4 to +13) and category: Definite (>=9), Probable (5-8), Possible (1-4), Doubtful (<=0). Reference: Naranjo et al. (1981) Clin Pharmacol Ther 30:239-245.

> **Note:** This tool routes through an external execution backend. If `EXECUTION_BACKEND_URL` is unset on the server, calls return JSON-RPC error `-32603 "Tool execution backend not configured"`. Tools with `backend: native` execute in-process and are always callable.

## Agent metadata

- `idempotent`: unknown
- `read_only`: unknown
- `expected_latency_ms`: unknown (not yet contract-tested)
- `cost_tokens_estimate`: unknown

## Input schema

- `drug` *string* — Suspected drug name
- `event` *string* — Adverse event term
- `q1_previous_reports` *string* (required) — Previous conclusive reports on this reaction? (yes/no/unknown)
- `q2_temporal_relationship` *string* (required) — Event appeared after suspected drug was given? (yes/no/unknown)
- `q3_dechallenge` *string* (required) — ADR improved when drug was discontinued? (yes/no/unknown)
- `q4_rechallenge` *string* (required) — ADR reappeared when drug was readministered? (yes/no/unknown)
- `q5_alternative_causes` *string* (required) — Alternative causes could explain the reaction? (yes/no/unknown)
- `q6_placebo_response` *string* (required) — Reaction appeared when placebo was given? (yes/no/unknown)
- `q7_drug_concentration` *string* (required) — Drug detected in blood in toxic concentration? (yes/no/unknown)
- `q8_dose_response` *string* (required) — Reaction more severe with increased dose? (yes/no/unknown)
- `q9_previous_experience` *string* (required) — Patient had similar reaction to same or similar drugs? (yes/no/unknown)
- `q10_objective_evidence` *string* (required) — ADR confirmed by objective evidence? (yes/no/unknown)

## Example call

```json
POST /api/mcp
Content-Type: application/json

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "station__pv-engine__assess-naranjo",
    "arguments": {
      "q1_previous_reports": "",
      "q2_temporal_relationship": "",
      "q3_dechallenge": "",
      "q4_rechallenge": "",
      "q5_alternative_causes": "",
      "q6_placebo_response": "",
      "q7_drug_concentration": "",
      "q8_dose_response": "",
      "q9_previous_experience": "",
      "q10_objective_evidence": ""
    }
  }
}
```

## Related

- [/tools](/tools) — all 3062 tools
- [/tools/pv-engine__assess-naranjo](/tools/pv-engine__assess-naranjo) — HTML page
- [/tools/pv-engine__assess-naranjo/json](/tools/pv-engine__assess-naranjo/json) — JSON form (agent-friendly)
- [/api/mcp](/api/mcp) — endpoint
- [/AGENTS.md](/AGENTS.md) — agent guide