# pk-clearance

`station__pharmacokinetics__pk-clearance` · external (needs EXECUTION_BACKEND_URL configured) · domain `pharmacokinetics` · pv-relevance `pv-core`

Calculate systemic clearance from dose and AUC. CL = (F × Dose) / AUC. For IV: F = 1.0. For oral: F < 1.0 reflects first-pass metabolism.

> **Note:** This tool routes through an external execution backend. If `EXECUTION_BACKEND_URL` is unset on the server, calls return JSON-RPC error `-32603 "Tool execution backend not configured"`. Tools with `backend: native` execute in-process and are always callable.

## Agent metadata

- `idempotent`: unknown
- `read_only`: unknown
- `expected_latency_ms`: unknown (not yet contract-tested)
- `cost_tokens_estimate`: unknown

## Input schema

- `auc` *number* (required) — Area under the curve (mg·h/L)
- `bioavailability` *number* (required)
- `dose` *number* (required) — Administered dose (mg)

## Example call

```json
POST /api/mcp
Content-Type: application/json

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "station__pharmacokinetics__pk-clearance",
    "arguments": {
      "auc": 0,
      "bioavailability": 0,
      "dose": 0
    }
  }
}
```

## Related

- [/tools](/tools) — all 3062 tools
- [/tools/pharmacokinetics__pk-clearance](/tools/pharmacokinetics__pk-clearance) — HTML page
- [/tools/pharmacokinetics__pk-clearance/json](/tools/pharmacokinetics__pk-clearance/json) — JSON form (agent-friendly)
- [/api/mcp](/api/mcp) — endpoint
- [/AGENTS.md](/AGENTS.md) — agent guide