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run-ich-e1-population-exposure

station__microgram__run-ich-e1-population-exposure external (needs EXECUTION_BACKEND_URL) microgram pv-core Constructa Configa

ICH E1 Population Exposure decision tree. Routes minimum safety database size for drugs intended for long-term treatment of non-life-threatening conditions. Standard: 1500 total, 300-600 at 6 months, 100 at 12 months. Handles 5 exception categories and regional variants (US priority, Japan).

Taxonomy

Linnaean classification joined from the algovigilance taxonomy index via the parent config's rank.

Rank	Value
domain	`Substrata`
kingdom	`Constructa`
phylum	`Configa`
class	`station-config`
order	`microgram`
family	`mcp-tool-config`

Characteristics:

substrate: config
domain: pv
lifecycle: continuous
authority: read
compounding: producer
io: agent-request → tool-response

Input schema

treatment_duration stringrequired — long_term (>6 months) or short_term
condition_severity stringrequired — non_life_threatening or life_threatening
has_exception boolean — Whether an exception condition applies
exception_type string — late_developing_ade, low_frequency_ade, small_benefit, background_morbidity, small_population
region string — us, eu, japan
is_priority_drug boolean — US priority drug designation

Example call

POST /api/mcp
Content-Type: application/json

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "station__microgram__run-ich-e1-population-exposure",
    "arguments": {
      "treatment_duration": "",
      "condition_severity": ""
    }
  }
}

How to invoke from a client

From any MCP-aware client, add https://algovigilance.com/api/mcp as an MCP server, then call this tool by name. From a raw HTTP client, send the JSON-RPC body above to /api/mcp.

Agent-friendly formats

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All tools (3062 live)
/api/mcp — endpoint
/AGENTS.md — agent guide
/tools/microgram__run-ich-e1-population-exposure/raw.md — this page's Markdown twin