# run-e2d-signal-communication

`station__microgram__run-e2d-signal-communication` · external (needs EXECUTION_BACKEND_URL configured) · domain `microgram` · pv-relevance `pv-core`

ICH E2D Section 7: Determines the regulatory communication action required when a safety signal is identified post-approval — from routine PSUR inclusion to urgent Dear Healthcare Professional letter

> **Note:** This tool routes through an external execution backend. If `EXECUTION_BACKEND_URL` is unset on the server, calls return JSON-RPC error `-32603 "Tool execution backend not configured"`. Tools with `backend: native` execute in-process and are always callable.

## Agent metadata

- `idempotent`: unknown
- `read_only`: unknown
- `expected_latency_ms`: unknown (not yet contract-tested)
- `cost_tokens_estimate`: unknown

## Input schema

- `authority_notified` *boolean* (required) — Input parameter: authority_notified
- `imminent_patient_risk` *boolean* (required) — Input parameter: imminent_patient_risk
- `signal_strength` *string* (required) — Input parameter: signal_strength
- `affects_labeling` *boolean* (required) — Input parameter: affects_labeling
- `signal_confirmed` *boolean* (required) — Input parameter: signal_confirmed

## Example call

```json
POST /api/mcp
Content-Type: application/json

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "station__microgram__run-e2d-signal-communication",
    "arguments": {
      "authority_notified": false,
      "imminent_patient_risk": false,
      "signal_strength": "",
      "affects_labeling": false,
      "signal_confirmed": false
    }
  }
}
```

## Related

- [/tools](/tools) — all 3062 tools
- [/tools/microgram__run-e2d-signal-communication](/tools/microgram__run-e2d-signal-communication) — HTML page
- [/tools/microgram__run-e2d-signal-communication/json](/tools/microgram__run-e2d-signal-communication/json) — JSON form (agent-friendly)
- [/api/mcp](/api/mcp) — endpoint
- [/AGENTS.md](/AGENTS.md) — agent guide