# run-e2d-ethics-committee-notification

`station__microgram__run-e2d-ethics-committee-notification` · external (needs EXECUTION_BACKEND_URL configured) · domain `microgram` · pv-relevance `pv-core`

ICH E2D Section 4.2: Determines whether a post-approval serious unexpected ADR requires notification to ethics committees and investigators

> **Note:** This tool routes through an external execution backend. If `EXECUTION_BACKEND_URL` is unset on the server, calls return JSON-RPC error `-32603 "Tool execution backend not configured"`. Tools with `backend: native` execute in-process and are always callable.

## Agent metadata

- `idempotent`: unknown
- `read_only`: unknown
- `expected_latency_ms`: unknown (not yet contract-tested)
- `cost_tokens_estimate`: unknown

## Input schema

- `is_serious` *boolean* (required) — Input parameter: is_serious
- `is_unexpected` *boolean* (required) — Input parameter: is_unexpected
- `is_fatal` *boolean* (required) — Input parameter: is_fatal
- `ongoing_study_involvement` *boolean* (required) — Input parameter: ongoing_study_involvement
- `is_life_threatening` *boolean* (required) — Input parameter: is_life_threatening

## Example call

```json
POST /api/mcp
Content-Type: application/json

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "station__microgram__run-e2d-ethics-committee-notification",
    "arguments": {
      "is_serious": false,
      "is_unexpected": false,
      "is_fatal": false,
      "ongoing_study_involvement": false,
      "is_life_threatening": false
    }
  }
}
```

## Related

- [/tools](/tools) — all 3062 tools
- [/tools/microgram__run-e2d-ethics-committee-notification](/tools/microgram__run-e2d-ethics-committee-notification) — HTML page
- [/tools/microgram__run-e2d-ethics-committee-notification/json](/tools/microgram__run-e2d-ethics-committee-notification/json) — JSON form (agent-friendly)
- [/api/mcp](/api/mcp) — endpoint
- [/AGENTS.md](/AGENTS.md) — agent guide