# run-e2a-ae-vs-adr

`station__microgram__run-e2a-ae-vs-adr` · external (needs EXECUTION_BACKEND_URL configured) · domain `microgram` · pv-relevance `pv-core`

ICH E2A Section 2: Classify whether an event is an Adverse Event (AE) or Adverse Drug Reaction (ADR) based on causal relationship and temporal association

> **Note:** This tool routes through an external execution backend. If `EXECUTION_BACKEND_URL` is unset on the server, calls return JSON-RPC error `-32603 "Tool execution backend not configured"`. Tools with `backend: native` execute in-process and are always callable.

## Agent metadata

- `idempotent`: unknown
- `read_only`: unknown
- `expected_latency_ms`: unknown (not yet contract-tested)
- `cost_tokens_estimate`: unknown

## Input schema

- `temporal_association` *boolean* (required) — Input parameter: temporal_association
- `reasonable_causal_relationship` *string* (required) — Input parameter: reasonable_causal_relationship
- `occurred_during_study` *boolean* (required) — Input parameter: occurred_during_study

## Example call

```json
POST /api/mcp
Content-Type: application/json

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "station__microgram__run-e2a-ae-vs-adr",
    "arguments": {
      "temporal_association": false,
      "reasonable_causal_relationship": "",
      "occurred_during_study": false
    }
  }
}
```

## Related

- [/tools](/tools) — all 3062 tools
- [/tools/microgram__run-e2a-ae-vs-adr](/tools/microgram__run-e2a-ae-vs-adr) — HTML page
- [/tools/microgram__run-e2a-ae-vs-adr/json](/tools/microgram__run-e2a-ae-vs-adr/json) — JSON form (agent-friendly)
- [/api/mcp](/api/mcp) — endpoint
- [/AGENTS.md](/AGENTS.md) — agent guide