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run-bradford-hill-multi-criterion

station__microgram__run-bradford-hill-multi-criterion external (needs EXECUTION_BACKEND_URL) microgram pv-core Constructa Configa

Full 5-criterion Bradford Hill causality assessment: temporal association → signal comparison → dose-response → rechallenge → Naranjo. The most comprehensive single-call causality evaluation in the platform.

Taxonomy

Linnaean classification joined from the algovigilance taxonomy index via the parent config's rank.

Rank	Value
domain	`Substrata`
kingdom	`Constructa`
phylum	`Configa`
class	`station-config`
order	`microgram`
family	`mcp-tool-config`

Characteristics:

substrate: config
domain: pv
lifecycle: continuous
authority: read
compounding: producer
io: agent-request → tool-response

Input schema

drug_start_to_event_days integerrequired — Days from drug initiation to adverse event onset
event_before_drug booleanrequired — Event occurred before drug was started (dechallenge violation)
signal_a numberrequired — PRR or signal strength for the drug of interest
signal_b numberrequired — PRR or signal strength for comparator drug
threshold numberrequired — Signal detection threshold (typically 2.0)
low_dose_rate numberrequired — Adverse event rate per 100 patients at low dose
mid_dose_rate numberrequired — Adverse event rate per 100 patients at mid dose
high_dose_rate numberrequired — Adverse event rate per 100 patients at high dose
baseline_rate numberrequired — Background rate of this event in the general population per 100 patients
first_exposure_rate numberrequired — Event rate per 100 patients on first drug exposure
rechallenge_rate numberrequired — Event rate per 100 patients on re-exposure after dechallenge
naranjo_score integerrequired — Naranjo ADR probability score (0-13)

Example call

POST /api/mcp
Content-Type: application/json

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "station__microgram__run-bradford-hill-multi-criterion",
    "arguments": {
      "drug_start_to_event_days": 0,
      "event_before_drug": false,
      "signal_a": 0,
      "signal_b": 0,
      "threshold": 0,
      "low_dose_rate": 0,
      "mid_dose_rate": 0,
      "high_dose_rate": 0,
      "baseline_rate": 0,
      "first_exposure_rate": 0,
      "rechallenge_rate": 0,
      "naranjo_score": 0
    }
  }
}

How to invoke from a client

From any MCP-aware client, add https://algovigilance.com/api/mcp as an MCP server, then call this tool by name. From a raw HTTP client, send the JSON-RPC body above to /api/mcp.

Agent-friendly formats

Working inside an AI assistant? Use the Copy for AI button at the top of this page (or view the raw Markdown) to paste a clean, token-budgeted version of this tool's contract into your conversation.

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/tools/microgram__run-bradford-hill-multi-criterion/raw.md — this page's Markdown twin