# run-bradford-hill-evidence

`station__microgram__run-bradford-hill-evidence` · external (needs EXECUTION_BACKEND_URL configured) · domain `microgram` · pv-relevance `pv-core`

Bradford Hill evidence assessment: signal comparison → dose-response classification → Naranjo causality. A 3-criterion causality chain using cross-variable comparison micrograms.

> **Note:** This tool routes through an external execution backend. If `EXECUTION_BACKEND_URL` is unset on the server, calls return JSON-RPC error `-32603 "Tool execution backend not configured"`. Tools with `backend: native` execute in-process and are always callable.

## Agent metadata

- `idempotent`: unknown
- `read_only`: unknown
- `expected_latency_ms`: unknown (not yet contract-tested)
- `cost_tokens_estimate`: unknown

## Input schema

- `signal_a` *number* (required) — PRR or signal strength for the drug of interest
- `signal_b` *number* (required) — PRR or signal strength for a comparator drug in the same class
- `low_dose_rate` *number* (required) — Adverse event rate per 100 patients at low dose
- `mid_dose_rate` *number* (required) — Adverse event rate per 100 patients at mid dose
- `high_dose_rate` *number* (required) — Adverse event rate per 100 patients at high dose
- `naranjo_score` *integer* (required) — Naranjo ADR probability score (0-13)

## Example call

```json
POST /api/mcp
Content-Type: application/json

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "station__microgram__run-bradford-hill-evidence",
    "arguments": {
      "signal_a": 0,
      "signal_b": 0,
      "low_dose_rate": 0,
      "mid_dose_rate": 0,
      "high_dose_rate": 0,
      "naranjo_score": 0
    }
  }
}
```

## Related

- [/tools](/tools) — all 3062 tools
- [/tools/microgram__run-bradford-hill-evidence](/tools/microgram__run-bradford-hill-evidence) — HTML page
- [/tools/microgram__run-bradford-hill-evidence/json](/tools/microgram__run-bradford-hill-evidence/json) — JSON form (agent-friendly)
- [/api/mcp](/api/mcp) — endpoint
- [/AGENTS.md](/AGENTS.md) — agent guide