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Microgram: naranjo-causality

station__algovigilance__microgram-naranjo-causality native (always callable) algovigilance pv-core Constructa Configa

Naranjo Adverse Drug Reaction Probability Scale. Ten yes/no/unknown questions about the drug-event temporal and clinical relationship, producing a probability category: definite, probable, possible, or doubtful.

Taxonomy

Linnaean classification joined from the algovigilance taxonomy index via the parent config's rank.

Rank	Value
domain	`Substrata`
kingdom	`Constructa`
phylum	`Configa`
class	`station-config`
order	`algovigilance`
family	`mcp-tool-config`

Characteristics:

substrate: config
domain: pv
lifecycle: continuous
authority: read
compounding: producer
io: agent-request → tool-response

Input schema

previous_reports stringrequired — Are there previous conclusive reports on this reaction? (yes/no/unknown)
after_drug stringrequired — Did the adverse event appear after the drug was administered? (yes/no/unknown)
improved_on_discontinuation stringrequired — Did the AE improve when the drug was discontinued or a specific antagonist was administered? (yes/no/unknown)
reappeared_on_readministration stringrequired — Did the AE reappear when the drug was re-administered? (yes/no/unknown)
alternative_causes_ruled_out stringrequired — Are there alternative causes that could on their own have caused the reaction? (yes/no/unknown) — note: 'yes' means alternative causes EXIST (worse for causality).
reappeared_with_placebo stringrequired — Did the reaction reappear when a placebo was given? (yes/no/unknown)
drug_detected_in_blood stringrequired — Was the drug detected in blood (or other fluids) in toxic concentrations? (yes/no/unknown)
dose_dependent stringrequired — Was the reaction more severe when dose increased / less severe when dose decreased? (yes/no/unknown)
prior_similar_reaction stringrequired — Did the patient have a similar reaction to the same/similar drug previously? (yes/no/unknown)
confirmed_by_objective_evidence stringrequired — Was the AE confirmed by any objective evidence (lab values, vital signs, imaging)? (yes/no/unknown)

Example call

POST /api/mcp
Content-Type: application/json

{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "station__algovigilance__microgram-naranjo-causality",
    "arguments": {
      "previous_reports": "",
      "after_drug": "",
      "improved_on_discontinuation": "",
      "reappeared_on_readministration": "",
      "alternative_causes_ruled_out": "",
      "reappeared_with_placebo": "",
      "drug_detected_in_blood": "",
      "dose_dependent": "",
      "prior_similar_reaction": "",
      "confirmed_by_objective_evidence": ""
    }
  }
}

How to invoke from a client

From any MCP-aware client, add https://algovigilance.com/api/mcp as an MCP server, then call this tool by name. From a raw HTTP client, send the JSON-RPC body above to /api/mcp.

Agent-friendly formats

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